A "SMART" design for building individualized treatment sequences.

Introduction to SMART designs for the development of adaptive interventions: with application to weight loss research.

The management of many health disorders often entails a sequential, individualized approach whereby treatment is adapted and readapted over time in response to the specific needs and evolving status of the individual. Adaptive interventions provide one way to operationalize the strategies (e.g., continue, augment, switch, step-down) leading to individualized sequences of treatment. Often, a wid...

Using Sequential, Multiple Assignment, Randomized Trial (SMART) Designs to Build Individualized Treatment Sequences

SMARTer discontinuation trial designs for developing an adaptive treatment strategy.

OBJECTIVE Developing evidenced-based practices for the management of childhood psychiatric disorders requires research studies that address how to treat children during both the acute phase of the disorder and beyond. Given the selection of a medication for acute treatment, discontinuation trials are used to evaluate the effects of treatment duration (e.g., time on medication) and/or maintenanc...

Active vibration control of smart building frames by feedback controllers

In this paper the active vibration control of a four-story shear frame instrumented with piezoelectric actuators is presented. The piezoelectric actuators are hosted on the columns in two manners and the produced controlling forces by actuators are considered in the equation of motion. The smart structure modeling and control design is carried out using MATLAB software in state space form. Subs...

Designing a pilot sequential multiple assignment randomized trial for developing an adaptive treatment strategy.

There is growing interest in how best to adapt and readapt treatments to individuals to maximize clinical benefit. In response, adaptive treatment strategies (ATS), which operationalize adaptive, sequential clinical decision making, have been developed. From a patient's perspective an ATS is a sequence of treatments, each individualized to the patient's evolving health status. From a clinician'...